Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—a case report

In June 2016, a 61-year-old man was hospitalised for Enterobacter cloacae peritonitis and severe abdominal sepsis with disseminated intravascular coagulation, secondary to a diaphragmatic hernia with bowel strangulation. The patient had a prolonged hospital course complicated by gangrene of the peripheral extremities, resulting in the amputation of the lower limbs and the development of large necrotic pressure sores.

Three months after admission, the patient was transferred to the Queen Astrid military hospital for surgical management of the pressure sores. Wound cultures on admission revealed colonisation with, amongst others, multidrug-resistant P. aeruginosa. One month after admission, the patient developed septicaemia with colistin-only-sensitive P. aeruginosa. Intravenous colistin therapy was started.

Bacteriophages are increasingly put forward as safe alternatives or additions to antibiotic therapy. Historical reports show that they were efficaciously used via the intravenous route, especially in typhoid fever and Staphylococcus aureus bacteremia, but this is—as far as we know—the first contemporary report of intravenous bacteriophage monotherapy against P. aeruginosa septicaemia in humans.

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Soviet-Era Treatment Could Be The New Weapon In The War Against Antibiotic Resistance

Soviet-Era Treatment Could Be The New Weapon In The War Against Antibiotic Resistance

Every year an increasing number of health tourists are travelling to Eastern bloc countries to receive an old Soviet medical treatment, which could be the answer to the West’s crisis in antibiotics. Receiving life saving medical treatment a long way from home is never ideal, but for many of these patients phage therapy is the last in a long line of previously unsuccessful remedies used in the fight against chronic bacterial infections – which conventional Western antibiotics have been unable to shift. Phage therapy – the use of bacteria-specific parasitic viruses to kill pathogens could offer a viable alternative to deal with multi-drug resistant infections. Viruses that kill bacteria may sound like something out of a sci-fi film but phages have been used in this way for decades in Russia and Georgia – neither of which have the same issues surrounding antibiotic resistance that we do. It is this rapid rise of antibiotic resistance that has led the Western world to look to Georgia in a bid to find new ways to control bacterial infections.

Les bactériophages, des virus mangeurs de bactéries à la rescousse des antibiotiques

Les bactériophages, des virus mangeurs de bactéries à la rescousse des antibiotiques

Mya

Les bactériophages vont-ils venir à la rescousse des antibiotiques pour lutter contre ces bactéries, de plus en plus nombreuses, qui résistent à tous nos antibiotiques? En tout cas, ces gentils virus se nourrissent de ces bactéries pathogènes multirésistantes. Ils s'accrochent à la paroi de la bactérie, lui injectent son propre ADN, et force la bactérie à produire de nombreuses copies du bactériophage, ce qui conduit à la faire exploser littéralement. Au bout du processus, la bactérie va libérer 50 ou 100 clones qui vont partir à la recherche de nouvelles victimes.

Silk route to the acceptance and re-implementation of bacteriophage therapy

Expert round table on acceptance and re-implementation of bacteriophage therapy

This multidisciplinary expert panel opinion on bacteriophage therapy has been written in the context of a society that is confronted with an ever-increasing number of antibiotic resistant bacteria. To avoid the return to a pre-antibiotic era, alternative treatments are urgently needed. The authors aim to contribute to the opinion formation of relevant stakeholders on how to potentially develop an infrastructure and legislation that paves the way for the acceptance and re-implementation of bacteriophage therapy.

Phage therapy gets revitalized

The rise of antibiotic resistance rekindles interest in a century-old virus treatment.

Psyophage

"For decades, patients behind the Iron Curtain were denied access to some of the best antibiotics developed in the West. To make do, the Soviet Union invested heavily in the use of bacteriophages — viruses that kill bacteria — to treat infections. Phage therapy is still widely used in Russia, Georgia and Poland, but never took off elsewhere. “This is a virus, and people are afraid of viruses,” says Mzia Kutateladze, who is the head of the scientific council at the Eliava Institute in Tbilisi, which has been studying phages and using them to treat patients for nearly a century.

Now, faced with the looming spectre of antibiotic resistance, Western researchers and governments are giving phages a serious look. In March, the US National Institute of Allergy and Infectious Diseases listed phage therapy as one of seven prongs in its plan to combat antibiotic resistance. And at the American Society for Microbiology (ASM) meeting in Boston last month, Grégory Resch of the University of Lausanne in Switzerland presented plans for Phagoburn: the first large, multi-centre clinical trial of phage therapy for human infections, funded by the European Commission."