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Details
 

Introduction 

The University of Lausanne is a higher teaching and research institution composed of seven faculties where approximately 14,300 students and nearly 3,900 collaborators, professors, and researchers work and study. Ideally situated along the lake of Geneva, near Lausanne's city center, its campus brings together over 120 nationalities.

Presentation 

The Department of Fundamental Microbiology offers a position of Doctoral Student SNSF (on bacteriophage therapy for Staphylococcus aureus infections).

Job information

Expected start date in position : 01.01.2018

Contract length : 1 year, maximum 4 years

Activity rate : 100%

Workplace : University of Lausanne until 31/12/2018 and then either in Lausanne or at the Bern University Hospital - Department of Intensive Care Medicine. 

Your responsibilities

The Resch group (https://www.unil.ch/dmf/en/home/menuinst/research-units/gregory-resch.html) aims at developing new therapeutic phages and phage-lysins in a rational approach. Specifically, we isolate new bacteriophages active against the ESKAPE pathogens and evaluate their efficacity in different rodent models of infectious diseases amongst which infective endocarditis in rats. We also address fundamental aspects of phage-bacteria interactions such as bacterial resistance to phages and phage adaptation. The research project of the Doctoral Student SNSF will be on the development of new S. aureus therapeutic phages with a focus on the study of resistance mechanisms. A wide array of methods and technologies in microbiology, phage research and genomics will be applied. The project will provide an excellent scientific training with many opportunities for collaborations in a stimulating environment.

Your qualifications

Applicants should have a Master in biological science with experience in microbiology. Further experience with bacteriophages, animal experimentation, molecular biology, bacterial genomics and computational biology is an asset. The candidate should have a good command of English and be highly motivated to learn new experimental techniques to study phage-bacteria interactions.

 

What the position offers you 

We offer a nice working place in a multicultural, diversified and dynamic academic environment, opportunities for professional training.

Possibilities of continuous training, a lot of activities and other benefits to discover.

 

Contact for further information

Dr. Grégory Resch

Phone number : 0041 21 692 56 09

Your application

Deadline : 30.11.2017

Please include your full application (motivation letter, CV, list of publications and the contact details of two referees) in Word or PDF.
Only applications through this website will be taken into account.
We thank you for your understanding.

Additional information

Seeking to promote an equitable representation of men and women among its staff, the University encourages applications from women.

    

Details

In June 2016, a 61-year-old man was hospitalised for Enterobacter cloacae peritonitis and severe abdominal sepsis with disseminated intravascular coagulation, secondary to a diaphragmatic hernia with bowel strangulation. The patient had a prolonged hospital course complicated by gangrene of the peripheral extremities, resulting in the amputation of the lower limbs and the development of large necrotic pressure sores.

Three months after admission, the patient was transferred to the Queen Astrid military hospital for surgical management of the pressure sores. Wound cultures on admission revealed colonisation with, amongst others, multidrug-resistant P. aeruginosa. One month after admission, the patient developed septicaemia with colistin-only-sensitive P. aeruginosa. Intravenous colistin therapy was started.

Bacteriophages are increasingly put forward as safe alternatives or additions to antibiotic therapy. Historical reports show that they were efficaciously used via the intravenous route, especially in typhoid fever and Staphylococcus aureus bacteremia, but this is—as far as we know—the first contemporary report of intravenous bacteriophage monotherapy against P. aeruginosa septicaemia in humans.

More information

Details

 

Monash University: Microbiology in Bacteriophage

A PhD position is available to work with Dr Jeremy J. Barr at Monash University, School of Biological Sciences, in Melbourne, Australia. We are looking for motivated, talented and enthusiastic PhD students with an interest in microbiology. With cutting-edge interdisciplinary project, excellent resources, and a strong publication focus, the Barr Lab provides an outstanding opportunity for all students. To learn more, visit thebarrlab.org

Project details:
Bacteriophage are specialist viruses that infect bacteria and are the most abundant biological entities on the planet. Within our bodies, bacteriophages control and manipulate our bacterial microbiota, prevent infection and disease and have interactions with eukaryotic cells and surfaces. Our lab has demonstrated the interactions of bacteriophage with mucus layers that provides an antimicrobial layer (Barr et al., PNAS 2013, 2015). The aim of this PhD project is to investigate the interactions of bacteriophage with bacterial hosts and eukaryotic cells using in vitro experimental systems. In doing so, you will gain expertise in microbiology, bacteriophage biology, infectious diseases, next-generation sequencing, tissue culture, microfluidics and experimental biology.

Scholarship details:
The Barr Lab has three fully-funded scholarships available for domestic and international students interested in doing a PhD. The 3.5 year award includes all course fees and a $26,000 AUD per year tax-free stipend. Additional expenses for relocation, coursework and conference attendance will also be covered.

Monash and the School of Biological Sciences:
Monash is a member of the Group of Eight, a coalition of top Australian universities recognized for their excellence in teaching and research. The School of Biological Sciences is a dynamic unit with strengths in ecology, genetics and physiology and the nexus between these disciplines (monash.edu/science/about/schools/biological-sciences/). The University is located in Melbourne, one of the most liveable cities in the world and a cultural and recreational hub.

Application process:
Interested candidates should send their CV, academic transcripts and a brief outline of research interests and motivation to This email address is being protected from spambots. You need JavaScript enabled to view it. Applicants must possess a Bachelor's or equivalent degree with first-class Honours, MSc or MPhil degree in a relevant subject (e.g., microbiology, genetics, ecology). Review of applications will begin immediately and short-listed candidates will be contacted for more information and invited to interview.

Details

 

 

Seeking PhD student in Molecular Biosciences (A)

Ref. No. SU FV-3912-16

 

 

at the Department of Molecular Biosciences, The Wenner-Gren Institute. Closing date: 20 January 2017.

Research at the Department of Molecular Biosciences, The Wenner-Gren Institute (MBW) experimentally addresses fundamental problems in molecular cell biology, integrative biology, and infection and immunobiology. State-of-the art and advanced methodologies are applied in a professional research environment characterized by its well-established international profile. The institute has 30 research groups with a research staff of 170, of which 55 are PhD students. Read more about MBW on www.su.se/mbw.

Project description
A PhD position in bacteriophage (bacterial viruses or phages) biology is available in the laboratory headed by Associate professor Anders Nilsson. The general aim of the research carried out in the group is to investigate the coevolution of phages and their bacterial hosts while also investigating the function of uncharacterized phage genes.

The position will be located within the project "Bacteriophage lysins as Alternatives to Antimicrobial Treatment" funded by the Swedish research council FORMAS under Animal Health and Welfare (ANIHWA), a part of the EU collaborative ERA-NET. The main goal of this project is to develop phage derived lysins as potential alternatives to antibiotics in animal production. The research group's part of the project involves isolation and characterization of novel phages from environmental samples, genome sequencing as well as bioinformatic identification and characterization of lysin genes.

Qualification requirements
Graduate studies in molecular biosciences requires a completed university degree at an advanced level and education corresponding to at least 240 Swedish credits (hp), including at least 120 hp in molecular biology, biology, chemistry or similar and complementary subjects. Candidates should have successfully completed courses at an advanced level in molecular biosciences (60 hp), of which 30 hp represent independent research project work. Special consideration may be given to candidates that have other documented qualifications, obtained in Sweden or elsewhere, that are judged to have provided equivalent knowledge.

Selection
The selection among the eligible candidates will primarily be based on the preceived capacity to benefit from the training. The following criteria will be used to assess this capacity: the candidates’ documented knowledge in a relevant field of research, written and oral proficiency in English, the capacity for analytical thinking, the ability to collaborate, as well as creativity, initiative, and independence. The assessment will be based on previous experience and grades, the quality of the degree project, references, relevant experience, interviews, and the candidate’s written motivation for seeking the position.